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This phenomenon extends beyond the decline of individual hormones, representing a state of systemic anabolic withdrawal coupled with a pro-inflammatory endocrine shift, which concurrently undermines the maintenance of muscle and vascular integrity

Gut Microbiome and Leaky Gut The gut has more than 100 trillion bacteria [27], with an aggregate biomass of approximately 1.5 kg [28], composed of more than 200 microbial strains in an individual and more than 90% of the dominant bacterial species belonging to the phylum Firmicutes and Bacteroidetes [29,30]

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